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. 2024 Oct 30;11(6):e200320. doi: 10.1212/NXI.0000000000200320

Figure 3. IL-10 Producers Persist in the CSF Late in Treatment.

Figure 3

(A) Flow cytometric analysis and paired t test of CSF samples provided by 4 patients (represented by color) early and late in treatment showed no difference in the proportion of IL-10 producers between the 2 treatment time points (p = 0.445). (B) Within these IL-10 producers, paired t tests found no significant changes in relative proportions of nTregs, iTregs, or Th17 cells over the course of treatment (nTregs [p = 0.085], iTregs [p = 0.399], Th17 [p = 0.110]), suggesting that the persistent population of IL-10 producers does not change in composition. Symbol colors reflect the patient identity of each sample, consistent with those in panel B. iTregs = induced regulatory T cells; nTregs = natural regulatory T cells.