Table 1.
Participant | A | B | C | D | E | F | G | |||||
CSF collection time point | Early | Late | Early | Late | Early | Late | Early | Late | Early | Early | Late | Late |
Flow | + | + | + | + | + | + | + | + | — | — | — | — |
scRNA | — | — | — | — | + | + | + | + | + | + | + | + |
Clinical presentation | Headaches, communicating hydrocephalus | Communicating hydrocephalus, meningitis | Obstructive hydrocephalus, meningitis | Difficulty walking, spinal cord compression | Seizures | Ischemic stroke | Headaches, communicating hydrocephalus | |||||
New diagnosis vs. recurrence | New Diagnosis | Recurrence | Reccurence | Recurrence | New Diagnosis | Recurrence | Recurrence | |||||
On albendazole and/or praziquantel | Yes | Yes | No | Yes | Yes | Yes | No | Yes | No | No | Yes | Yes |
Time on anthelmintics (mo) | <1 | 4 | — | 3 | 1 | 6 | — | 60 | — | — | 3 | 8 |
Dexamethasone equivalent (mg) | 7.5 | 9 | 0 | 0.9 | 1.5 | 0.8 | 0 | 0 | 18 | 1.1 | 4 | 0.8 |
Steroid-sparing agents | — | — | — | — | — | Etanercept | Methotrexate | — | — | — | Etanercept, methotrexate | — |
T. solium qPCR (Cq) | 19.6 | 25.6 | 32.8 | 28.2 | 22.1 | 24.2 | 35.8 | 29 | 40 | 33.2 | 27.1 | 34.3 |
Taenia antigena (ng/mL) | 17,104 | 8,207 | >4,000 | 20 | 2,239 | 47 | 6,580 | 527 | 21 | 10 | 0 | 0 |
(—) Indicated field not applicable.
Capture ELISA TsG10, commercial ELISA, or B60/158 Luminex assay.