Figure 2.

Discovery of Potential Drug Targets for Acne Through Integrative Cohort and Mendelian Randomization Analyses. This figure presents a comprehensive visualization of our analytical approach, starting with a Manhattan plot (A) detailing the cohort analysis outcomes. Each point on the plot signifies a distinct protein, with the x-axis denoting the gene's chromosomal location and the y-axis displaying the p-value obtained from multivariate Cox regression analysis. The region between the two dotted lines adjacent to the x-axis delineates the significance threshold (p < 0.05). Points beyond this threshold indicate proteins whose adjusted p-values remain below 0.05 after false discovery rate (FDR) correction, highlighted in blue and annotated with their respective protein names. Adjacent to this, a volcano plot (B) illustrates the results from cis-Mendelian Randomization (cis-MR) analysis, plotting each protein by the effect size from MR analysis (x-axis) against its p-value (y-axis). Lastly, a Venn diagram (C) captures the overlap between significant findings in both cohort and cis-MR analyses, with the names of the intersecting proteins specified within the diagram.