Table 2.
Univariate and multivariable OS Cox regression landmark analysis for patients on treatment for at least 1 year.
| Univariate HR [95% CI] | p-value | Multivariable HR [95% CI] | p-value | |
|---|---|---|---|---|
| Thrombosis (as time-varying covariate) | 0.97 [0.44–2.17] | 0.95 | 1.22 [0.53–2.79] | 0.64 |
| Age as continuous variable (years) | 1.02 [0.98–1.06] | 0.38 | - | - |
| Sex (Male vs. Female) | 1.09 [.48–2.46] | 0.84 | - | - |
| BMI (overweight/obese vs. normal/underweight) | 1.59 [0.72–3.48] | 0.25 | - | - |
| BMI | ||||
| - Overweight vs. Normal/Underweight | 0.84 [0.27–2.61] | 0.77 | - | - |
| - Obese vs. Normal/Underweight | 2.63 [1.10–6.26] | 0.029 | - | - |
| - Obese BMI (Obese vs. Underweight/ Normal/Overweight BMI)a | 2.75 [1.21–6.24] | 0.02 | 2.64 [1.16–6.01] | 0.02 |
| WBC at diagnosis | 1.003 [1.001–1.004] | <0.01 | 1.003 [1.001–1.004] | <0.01 |
| CNS-3 vs. CNS-1 or CNS-2 | 1.94 [0.26–14.36] | 0.52 | - | - |
| Immunophenotype B- vs. T-ALL | 5.09 [1.20–21.60] | 0.03 | 4.74 [1.10–20.39] | 0.04 |
| Hyperdiploid (yes vs. no) | 1.21 [.41–3.52] | 0.73 | - | - |
| MLL rearrangement (yes vs. no) | 1.29 [0.17–9.53] | 0.81 | - | - |
| Weeks of Asparaginase | 0.96 [0.93–1.00] | 0.062 | 0.97 [0.93–1.00] | 0.08 |
HR hazard ratio, CI confidence interval, BMI body mass index, WBC white blood cells, CNS central nervous system, ALL acute leukemia lymphoma, MLL mixed lineage leukemia, BMI body mass index.
aDichotomous obese variable (obese BMI vs. underweight/normal/overweight BMI) included in multivariable model over other BMI variables, given higher significance.