Table 1.
Characteristics of patients who underwent WBRT for brain metastases
| Patients (n = 328) | ||
|---|---|---|
| Sex | Male | 145 (44%) |
| Female | 183 (56%) | |
| Age, median (range), y | 63 (29–85) | |
| Karnofsky Performance Status | < 70 | 58 (18%) |
| 70–80 | 170 (52%) | |
| 90–100 | 100 (30%) | |
| Primary tumor histology | Non-small cell lung cancer | 135 (41%) |
| Breast | 73 (22%) | |
| Small cell lung cancer | 42 (13%) | |
| Melanoma | 30 (9%) | |
| Other | 48 (15%) | |
| Number of brain metastases | ≤ 3 | 79 (24%) |
| 4–9 | 77 (23%) | |
| ≥ 10 | 172 (52%) | |
| Leptomeningeal disease | Yes | 56 (17%) |
| No | 272 (83%) | |
| Extracranial disease | Yes | 262 (80%) |
| No | 66 (20%) | |
| Primary tumor controlled | Yes | 159 (48%) |
| No | 169 (52%) | |
| WBRT regimen | 10 × 3 Gy | 210 (64%) |
| 5 × 4 Gy | 82 (25%) | |
| 6 × 4 Gy | 12 (4%) | |
| Other | 24 (7%) | |
| Boost to macroscopic disease | Yes | 37 (11%) |
| No | 291 (89%) |
Abbreviations: WBRT whole brain radiation therapy