Table 3.

Logistic regression analysis presenting the association between neonatal comorbidities and pediatric chronic disease (asthma and AD)

Comorbidity	Asthma	Early asthma	Severe asthma	AD	Early AD	Severe AD
RDS	1.09 (1.05–1.14)	1.16 (1.06–1.26)	1.11 (0.98–1.27)	0.91 (0.88–0.95)	0.89 (0.84–0.93)	0.93 (0.87–1.00)
BPD	1.29 (1.21–1.37)	1.36 (1.20–1.55)	1.55 (1.30–1.85)	0.86 (0.80–0.92)	0.81 (0.74–0.89)	0.77 (0.67–0.88)
PDA	1.12 (1.06–1.18)	1.01 (0.90–1.13)	1.36 (1.17–1.59)	0.95 (0.90–1.00)	0.93 (0.87–1.00)	0.88 (0.79–0.98)
Pulmonary hypertension	1.16 (1.01–1.33)	1.29 (0.98–1.70)	1.25 (0.87–1.85)	1.10 (0.94–1.28)	1.10 (0.91–1.35)	1.01 (0.74–1.36)
NEC	0.93 (0.83–1.04)	0.90 (0.71–1.15)	0.68 (0.48–0.97)	0.87 (0.77–0.99)	0.97 (0.82–1.14)	0.73 (0.56–0.94)
IVH	1.02 (0.96–1.08)	0.98 (0.86–1.11)	0.88 (0.73–1.06)	1.00 (0.94–1.06)	0.98 (0.91–1.06)	1.04 (0.93–1.16)
Hypothyroidism	1.15 (1.08–1.23)	1.02 (0.88–1.18)	1.14 (0.93–1.38)	1.08 (1.01–1.16)	1.04 (0.95–1.13)	1.11 (0.98–1.26)
Neonatal sepsis	1.07 (1.03–1.13)	0.99 (0.90–1.10)	1.30 (1.13–1.48)	1.04 (0.99–1.09)	1.06 (0.99–1.12)	1.07 (0.98–1.16)
Neonatal jaundice	1.04 (1.00–1.08)	1.07 (0.98–1.17)	1.04 (0.91–1.19)	1.04 (0.99–1.08)	1.07 (1.01–1.12)	1.08 (1.00–1.16)
ROP	1.09 (1.05–1.13)	1.06 (0.97–1.14)	1.20 (1.06–1.35)	1.04 (1.00–1.07)	1.03 (0.98–1.08)	1.00 (0.94–1.07)

Adjusted for sex, residence, socioeconomic status, maternal asthma, maternal AD, maternal GDM, cesarean section, PIH

Numbers are expressed as odds ratios (95% confidence interval). Abbreviations: AD, atopic dermatitis; RDS, respiratory distress syndrome; BPD, bronchopulmonary dysplasia; NEC, necrotizing enterocolitis; IVH, intraventricular hemorrhage; PDA, patent ductus arteriosus; ROP, retinopathy of prematurity