Table 4.
Genes within or close to the DMRs associated with tinnitus, and their associations with traits and diseases (obtained with a Harmonizome search engine: https://maayanlab.cloud/Harmonizome/)
| DMR# | Genes within DMR | Gene name | Gene-disease associations (obtained with GAD and CDT databases) | High-level gene-disease associations |
|---|---|---|---|---|
| DMRs 2 and 5 | HLA-DPB2 | Major histocompatibility complex, class II, DP beta 2 (pseudogene) | Abortion—spontaneous, creatinine, electrocardiography, glomerulonephritis, myocardial infarction, tunica media, systemic sclerosis, | Cardiovascular, immune, metabolic, renal, reproduction |
| DMR 3 | PM20D1 | Peptidase M20 domain containing 1 | Human immunodeficiency virus disease, Parkinson’s disease | Infection, neurological |
| DMR 4 | TMEM18 | Transmembrane protein 18 | Body mass index, body weight, obesity, celiac disease, type 2 diabetes, anorexia nervosa, asthma | Immune, metabolic, psychological |
| SNTG2 | Syntrophin gamma 2 | Eosinophils, child development disorders, autistic disorder, drug-induced liver injury, hyperplasia, necrosis | Hematological, metabolic | |
| DMR 6 | MUC4 | Mucin 4, cell surface associated | Asthma, bronchiolitis, respiratory syncytial virus infections, atopy | Immune, infection, reproduction |
| DMR 9 | LCLAT1 | Lysocardiolipin acyltransferase 1 | Alcoholism, hyperplasia, inflammation | Cardiovascular, chemical dependency |
| DMR 10 | miR886 | A non-coding RNA | Not reported (miRNA) | Not reported |
| DMR 13 | miR596 | A non-coding RNA | Not reported (miRNA) | Not reported |
| DMR 17 | TXNRD1 | Thioredoxin reductase 1 | Acquired immunodeficiency syndrome, adenoma, colorectal neoplasms, aging—telomere length, amyotrophic lateral sclerosis, glucose, arsnic exposure, breast cancer, cognitive traits | Aging, cancer, infection, metabolic, neurological, pharmacogenomic |
| EID3 | EP300 Interacting Inhibitor of Differentiation 3 | Inflammation, drug-induced liver injury, kindness diseases, necrosis | Metabolic | |
| DMR 21 | RUNX1 | RUNX family transcription factor 1 | Arthritis, rheumatoid, bilirubin, bone mineral density, colitis, Crohn’s disease, esophageal neoplasms, hepatopulmonary syndrome, liver cirrhosis, leukemia, myeloid, myelodysplastic syndromes, stroke, tobacco use disorder, type 2 diabetes, edema rosiglitazone, Vitamin D, asthma, chronic myelomonocytic leukemia, diabetes, type 1, leukemia, lupus erythematosus, prostate cancer, psoriasis, rheumatoid arthritis, schizophrenia | Cancer, chemical dependency, hematological, immune, metabolic, neurological, other, pharmacogenomic |
| DMR 22 | SDHAP3 | SDHA pseudogene 3 | Blood pressure, cholesterol, echocardiography, erythrocytes, hemoglobin | Cardiovascular, hematological, metabolic |
| DMR 23 | RUFY1 | RUN and FYVE domain containing 1 | Amyotrophic lateral sclerosis | Neurological |
| DMR 24 | NUDT12 | Nudix hydrolase 12 | Alanine transaminase, hearing loss, arteries, blood proteins, body height, body weights and measures, platelet count, tobacco use disorder, waist circumference, | Cardiovascular, chemical dependency, developmental, hematological, metabolic, other |
| DMR 27 | TTC23 | Tetratricopeptide Repeat Domain 23 | Erythrocytes, stroke, drug-induced liver injury | Hematological, cardiovascular |
| DMR 32 | CERS3 (LASS3) | Ceramide Synthase 3 | Albumins, triglycerides | Metabolic |
| DMR 28 | SLC43A2 | Solute carrier family 43 member 2 | Tobacco use disorder, type 2 diabetes, edema, rosiglitazone | Chemical dependency, pharmacogenomic |
| DMR 14 | C10orf11 (LRMDA) | Leucine Rich Melanocyte Differentiation Associated | Blood flow velocity, calcium, coronary artery disease, erythrocyte count, respiratory function tests, tamoxifen, tobacco use disorder, uric acid | Not reported |
| DMR 33 | HLA-DQB1 | Major histocompatibility complex, class II, DQ beta 1(HLA-DQB1) | Abortion, acquired immunodeficiency syndrome, tuberculosis, Addison disease, allergies, arthritis, asthma, diabetes type 1 and type 2, autoimmune diseases, rheumatic fever, Whipple disease, and more | Immune, infection, cancer, metabolic, normal variation, cardiovascular, reproduction, neurological, hematological, psychiatric, renal, vision, pharmacogenomic |
| DMR 1 | NADK | NAD kinase(NADK) | Tobacco use disorder | Chemical dependency |
| DMR 34 | C4orf37 (STPG2) | Sperm Tail PG-Rich Repeat Containing 2 | Tobacco use disorder | Chemical dependency |
| DMR 15 | SZRD1 | SUZ RNA Binding Domain Containing 1 | Hypertrophy, liver neoplasms, kidney diseases, inflammation, weight gain, and more | Not reported |
| MFAP2 | Microfibril Associated Protein 2 | Body height, exfoliation syndrome, glaucoma, respiratory function tests | Developmental, vision, cardiovascular | |
| DMR 18 | NUP210L | Nucleoporin 210 kDa-Like | ||
| TPM3 | Tropomyosin 3 | Nemaline myopathy | Other | |
| DMR 35 | INTS9 | Integrator Complex Subunit 9 | ||
| DMR 36 | EFCAB4B | EF-hand calcium binding domain 4B | Not reported | Not reported |
| DMR 37 | SLC2A14 | Solute Carrier Family 2 Member 14 | Alcoholism | Chemical dependency |
| DMR 38 | TRMT12 | TRNA Methyltransferase 12 Homolog | Infertility (male), drug-induced liver injury, necrosis, inflammation, cardiovascular abnormalities | Not reported |