TABLE 2.
List of differentially regulated proteins in AP treated group vs. control group. Positive fold-change value denotes up-accumulation and negative fold change value denotes down-accumulation in comparison with control.
| Gene symbol | Protein name | p-value (FDR) | Fold change (log2 vs. control) | Biological process |
|---|---|---|---|---|
| Apoa2 | Apolipoprotein A-II | 0.00415844 | 1.43 | Lipid transport and metabolism, retinoid transport, chylomicron remodeling |
| Acot7 | Cytosolic acyl coenzyme A thioester hydrolase | 0.028980935 | 1.18 | Fatty acid metabolism, lipid metabolism |
| Ces1c | Carboxylesterase 1C | 0.023659294 | 1.07 | Lipid catabolism, response to metal ions |
| Rab11b | Ras-related protein Rab-11B | 0.035000507 | 1.03 | Intracellular transport of proteins, organization of vesicles |
| Rab11a | Ras-related protein Rab-11A | 0.028005962 | 0.98 | Cell cycle, protein transport |
| Dnajc3 | DnaJ homolog subfamily C member 3 | 0.013974559 | 0.81 | Reaction to stress, regulation of translation, unfolded protein stress |
| Fh1 | Fumarate hydratase, mitochondrial | 0.034636547 | 0.77 | DNA damage, DNA repair, tricarboxylic acid cycle |
| Ighm | Immunoglobulin heavy constant mu | 0.034548178 | 0.53 | Immune response |
| Mcm6 | DNA replication licensing factor MCM6 | 0.0491043 | 0.41 | Cell cycle, DNA replication |
| P4hb | Protein disulfide-isomerase | 0.041677687 | 0.25 | Protein folding, ER stress response |
| Hspa5 | Endoplasmic reticulum chaperone BiP | 0.044074358 | 0.18 | Unfolded protein response (UPR) |
| Rplp2 | Large ribosomal subunit protein P2 | 0.042595638 | 0.14 | Ribosome biogenesis, translation |
| Gm6525 | Predicted pseudogene 6525 | 0.007133671 | −0.30 | Ribosome biogenesis, translation |
| Atp5j | ATP synthase-coupling factor 6, mitochondrial | 0.008585462 | −0.32 | Ion transport, ATP metabolism |
| Rps3 | Small ribosomal subunit protein S3 | 0.005865099 | −0.47 | Regulation of transcription and translation, cell cycle |
| Hnrnpk | Heterogeneous nuclear ribonucleoprotein K | 0.010241351 | −0.57 | mRNA processing, mRNA splicing, transcription, regulation of transcription |
| Hmgb1 | High mobility group protein B1 | 0.004082575 | −0.72 | Innate and acquired immunity, autophagy, chemotaxis, DNA damage, recombination and repair, immunity, inflammatory response |
| Anxa7 | Annexin A7 | 0.027257018 | −0.84 | Cell signaling, cell proliferation, integrin binding, ECM interactions |
| Hnrnpd | Heterogeneous nuclear ribonucleoprotein D0 | 0.004487521 | −1.07 | Biological rhythms, regulation of transcription |
| Rpl36a | Ribosomal protein L36A | 0.012994618 | −1.08 | Translation, ribosome biogenesis |
| Cdc42 | Cell division control protein 42 homolog | 0.032738061 | −1.11 | Actin cytoskeleton organization, intercellular adhesion, regulation of cell growth and division, DNA replication, angiogenesis |
| Ddx3y | ATP-dependent RNA helicase DDX3Y | 0.026644555 | −1.22 | Initiation of translation |
| Syncrip | Heterogeneous nuclear ribonucleoprotein Q | 0.021065728 | −1.76 | RNA processing, translation |