Figure 7.

Kaplan-Meier survival curves of the glioblastoma patients grouped according to MGMT methylation status and tumor vascularity based on rCBF: (A) rCBF <1.8 with MGMT methylation (n=5); (B) rCBF <1.8 without MGMT methylation (n=19); (C) rCBF ≥1.8 with MGMT methylation (n=17); (D) rCBF ≥1.8 without MGMT methylation (n=9). There was no association between MGMT methylation status, OS and PFS in lower rCBF. However, patients with MGMT methylation had longer OS and PFS compared with those without MGMT methylation in higher vascularized tumors (rCBF ≥1.8; P<0.05). OS, Overall survival; PFS, progression-free survival; MGMT, O6-methylguanine DNA methyltransferase; rCBV, cerebral blood volume ratio; rCBF, cerebral blood flow ratio.