Table 2.
Logistic regression tests for e-Score quintile associations with colorectal cancer among all-male MVP validation sample (n = 113,752).
| Odds for colorectal cancer | ||||||
|---|---|---|---|---|---|---|
| Metrics | e-ScoreQuintile 1 (referent) | e-ScoreQuintile 2 | e-ScoreQuintile 3 | e-ScoreQuintile 4 | e-ScoreQuintile 5 | P for trend |
| GECCOa e-Score (median; range) | 8.1; 0–12.2 | 15.6; 12.2–18.7 | 21.9; 18.7–25.4 | 29.5; 25.4–34.7 | 43.3; 34.7–100.0 | |
| Number of participants | 22,751 | 22,750 | 22,751 | 22,750 | 22,750 | |
| Number (%) of colorectal cancer cases | 122 (0.54) | 112 (0.49) | 94 (0.41) | 130 (0.57) | 132 (0.58) | |
| Unadjusted modelbOR (95% CI) | 1.00 | 0.99 (0.77, 1.23) | 0.71 (0.55, 0.93) | 0.85 (0.66, 1.09) | 0.92 (0.72, 1.18) | 0.436 |
| Multivariable-adjusted modelcOR (95% CI) | 1.00 | 0.99 (0.77, 1.26) | 0.71 (0.55, 0.93) | 0.86 (0.67, 1.11) | 0.95 (0.74, 1.22) | 0.587 |
| Recalibratedd e-Score (median; range) | 32.5; 0–37.6 | 41.4; 37.6–44.7 | 47.8; 44.7–50.8 | 54.1; 50.8–57.9 | 63.1; 57.9–100.0 | |
| Number of participants | 22,751 | 22,749 | 22,752 | 22,749 | 22,751 | |
| Number (%) of colorectal cancer cases | 88 (0.39) | 99 (0.44) | 128 (0.56) | 119 (0.52) | 156 (0.69) | |
| Unadjusted modeleOR (95% CI) | 1.00 | 1.13 (0.84, 1.50) | 1.46 (1.11, 1.91) | 1.35 (1.03, 1.79) | 1.78 (1.37, 2.31) | <0.0001 |
| Multivariable-adjusted modelfOR (95% CI) | 1.00 | 1.12 (0.84, 1.49) | 1.44 (1.10, 1.89) | 1.34 (1.02, 1.77) | 1.79 (1.38, 2.33) | <0.0001 |
e-Score calculated using β estimates derived from a GECCO training model.
Unadjusted colorectal cancer modeled for GECCO e-Score.
GECCO e-Score multivariable adjusted: colorectal cancer modeled for GECCO e-Score, adjusted for age, race (Black, White, or unknown/underrepresented/multiple), and family history of colorectal cancer.
e-Score calculated using β estimates derived from a recalibrated e-Score training model.
Unadjusted colorectal cancer modeled for recalibrated e-Score.
Recalibrated e-Score multivariable adjusted: colorectal cancer modeled for recalibrated e-Score, adjusted for age, race (Black, White, or unknown/underrepresented/multiple), and family history of colorectal cancer.
Bold P value < 0.05 is significant.