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. 2024 Aug 28;5(9):101699. doi: 10.1016/j.xcrm.2024.101699

Figure 1.

Figure 1

Amino acid transport may be favored in FLC and diverted into translation

(A) Descriptive model embedded with omics data depicting transport of sugars, amino acids, and fatty acids in FLC. Proteomics data—n = 23 samples; metabolomics data—n = 26 samples.

(B) Descriptive model depicting the potential relationship between amino acid transport and protein translation in FLC. (A and B) Left side of each node—gradient red is increasing log2FC (FLC vs. NML) and gradient blue is decreasing log2FC; Right side of each node—gray is not significant and yellow is significant (proteins—FDR-adj p < 0.05; metabolites—FDR-adj p < 0.1); nodes associated with edges that have open arrowheads, proteins; double-line edges, transport; nodes associated with double-line edges, metabolites; SLC, solute carrier; CEAAs, conditionally essential amino acids; EAAs, essential amino acids; NEAAs, non-essential amino acids; BCAAs, branched-chain amino acids; ECM, extracellular matrix; green traffic light, stimulation.