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Proposed activity and observed products of MaCYP716AD4 and MaLFS. (A) Proposed reactions converting 6 to 8. (B) Off-target MaCYP71AD4 product (11) seen in the absence of MaL7AT16 (Figure S12). (C) Predicted formation of 7a via reduction of C23 aldehyde (proposed to be performed by endogenous N. benthamiana enzymes).
