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Graphical abstract. CLT promotes the ubiquitination and degradation of ECM1 in IgAN macrophages to regulate STAT5 phosphorylation, leading to decreased secretion of IL-6 and TNF-α and upregulation of Arg-1 expression, thereby promoting the transformation of pro-inflammatory M1-like macrophages to reparative M2-like macrophages and reducing inflammatory damage in IgAN.
