Figure 8.

The schematic diagram illustrating how truncated AIMP1 stimulates DPCs to promote hair growth. Wnt3a stimulation induces AIMP1 cleavage via MMP1 activation in hair follicle stem cells (HFSCs), leading to the release of a truncated form of AIMP1. The secreted AIMP1 enhances hair growth by upregulating hair growth-promoting molecules in dermal papilla cells (DPCs), subsequently activating β-catenin, ALP, p-AKT, and p-ERK signaling pathways, thereby facilitating anagen transition and promoting hair growth.