. 2024 Oct 31;24:1326. doi: 10.1186/s12913-024-11679-5

Table 4.

Cost-effectiveness results of REGAIN intervention compared to usual care at 12 months (£, 2022)

	REGAIN cost (£) (95% CI)	Usual care cost (£) (95% CI)	Incremental costs (£) (95% CI)	REGAIN QALY (95% CI)	Usual care QALY (95% CI)	Incremental QALYs (95% CI)	ICER (£/QALY)	Pce¹	Pce²	Pce³	NMB¹ (95% CI)	NMB² (95% CI)	NMB³ (95% CI)
Base case ^abc	1987 (1666 to 2307)	1681 (1406 to 1955)	305 (-123 to 732)	0.582 (0.555 to 0.608)	0.556 (0.530 to 0.583)	0.026 (-0.005 to 0.052)	11,941	0.596	0.714	0.836	78 (-538 to 683)	206 (-506 to 920)	461 (-458 to 1338)
Complete case ^ad	1884 (1561 to 2209)	1711 (1394 to 2030)	173 (-282 to 627)	0.600 (0.579 to 0.618)	0.567 (0.548 to 0.586)	0.032 (0.004 to 0.059)	5410	0.823	0.888	0.941	306 (-627 to 953)	466 (-285 to 1217)	785 (-200 to 1770)
Societal perspective ^abd	3995 (3204 to 4785)	3839 (3062 to 4616)	156 (-949 to 1260)	0.581 (0.562 to 0.601)	0.557 (0.538 to 0.575)	0.025 (-0.002 to 0.052)	6242	0.636	0.699	0.788	219 (-1261 to 1446)	343 (-950 to 1636)	593 (-860 to 2045)
Compliance data ^abd	1995 (1695 to 2295)	1676 (1380 to 1972)	319 (-103 to 741)	0.581 (0.562 to 0.601)	0.557 (0.538 to 0.575)	0.025 (-0.002 to 0.052)	12,708	0.573	0.691	0.815	58 (-741 to 674)	183 (-537 to 903)	434 (-516 to 1383)

REGAIN
cost (£)
(95% CI)

Usual care
cost (£)
(95% CI)

Incremental
costs (£)
(95% CI)

REGAIN
QALY
(95% CI)

Usual care
QALY
(95% CI)

Incremental
QALYs
(95% CI)

ICER
(£/QALY)

Pce¹

Pce²

Pce³

NMB¹
(95% CI)

NMB²
(95% CI)

NMB³
(95% CI)

Base case ^abc

1987

(1666 to 2307)

1681

(1406 to 1955)

305

(-123 to 732)

0.582

(0.555 to 0.608)

0.556

(0.530 to 0.583)

0.026

(-0.005 to 0.052)

11,941

0.596

0.714

0.836

(-538 to 683)

206

(-506 to 920)

461

(-458 to 1338)

Complete case ^ad

1884

(1561 to 2209)

1711

(1394 to 2030)

173

(-282 to 627)

0.600

(0.579 to 0.618)

0.567

(0.548 to 0.586)

0.032

(0.004 to 0.059)

5410

0.823

0.888

0.941

306

(-627 to 953)

466

(-285 to 1217)

785

(-200 to 1770)

Societal perspective ^abd

3995

(3204 to 4785)

3839

(3062 to 4616)

156

(-949 to 1260)

0.581

(0.562 to 0.601)

0.557

(0.538 to 0.575)

0.025

(-0.002 to 0.052)

6242

0.636

0.699

0.788

219

(-1261 to 1446)

343

(-950 to 1636)

593

(-860 to 2045)

Compliance data ^abd

1995

(1695 to 2295)

1676

(1380 to 1972)

319

(-103 to 741)

0.581

(0.562 to 0.601)

0.557

(0.538 to 0.575)

0.025

(-0.002 to 0.052)

12,708

0.573

0.691

0.815

(-741 to 674)

183

(-537 to 903)

434

(-516 to 1383)

^a Adjusted for age, gender, level of hospital care and presence of mental health symptoms

^b Imputed costs and QALYs

^c Estimates derived from non-parametric bootstrapping using 3000 replications

^d Estimates derived using parametric methods

NMB¹ NMB² NMB³ Mean NMB with 95% CI at cost effectiveness thresholds £15000, £20000, £30000

Pce¹ Pce² Pce³ Probability of cost-effectiveness at thresholds £15000, £20,000, and £30,000