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. 2002 May 15;30(10):2144–2153. doi: 10.1093/nar/30.10.2144

Figure 6.

Figure 6

Inhibition of supercoiling activity of M.smegmatis and E.coli DNA gyrase. Effect of fluoroquinolones on the supercoiling activity of wild-type M.smegmatis (A), E.coli (B) and ciprofloxacin-resistant M.smegmatis (C) DNA gyrase. Supercoiling assays were carried out in the presence of varying concentrations of ciprofloxacin (lanes 3–7) and moxifloxacin (lanes 8–12). Drugs were added at the time of reaction initiation. Lane 1, relaxed pUC18 DNA; lane 2, supercoiling reaction in the absence of drug.