Table 3.
Classification of Progression According to Rates of Change in Spectral-Domain Optical Coherence Tomography (SD OCT) Retinal Nerve Fiber Layer (RNFL) Thickness and Standard Automated Perimetry (SAP) Mean Deviation (MD) for Each Diagnosis and Level of Visual Field Severity at Baseline.
| Progression Rate Classificationa,b | Test | By Diagnosis | By SAP Severity | Overall (6,138 eyes) | |||||
|---|---|---|---|---|---|---|---|---|---|
| GS (2,649 eyes) | POAG (2,107 eyes) | Other (1,382 eyes) | Normal (1,703 eyes) | Mild (3,052 eyes) | Moderate (722 eyes) | Severe (661 eyes) | |||
| By individual groups | |||||||||
| Slow, n (%) | SD OCT | 2,118 (79.9) | 1,510 (71.7) | 875 (63.3) | 1,348 (79.2) | 2,171 (71.1) | 498 (69.0) | 486 (73.5) | 4,503 (73.4) |
| SAP | 2,567 (96.9) | 1,823 (86.5) | 1,189 (86.0) | 1,662 (97.5) | 2,872 (94.1) | 593 (82.1) | 452 (68.4) | 5,579 (90.9) | |
| Moderate, n (%) | SD OCT | 452 (17.1) | 510 (24.2) | 385 (27.9) | 307 (18.0) | 738 (24.2) | 175 (24.2) | 127 (19.2) | 1,347 (21.9) |
| SAP | 62 (2.3) | 228 (10.8) | 158 (11.4) | 35 (2.1) | 139 (4.6) | 93 (12.9) | 181 (27.4) | 448 (7.3) | |
| Fast, n (%) | SD OCT | 79 (3.0) | 87 (4.1) | 122 (8.8) | 48 (2.8) | 143 (4.7) | 49 (6.8) | 48 (7.3) | 288 (4.7) |
| SAP | 20 (0.8) | 56 (2.7) | 35 (2.6) | 6 (0.4) | 41 (1.3) | 36 (5.0) | 28 (4.2) | 111 (1.8) | |
| By cumulative groups | |||||||||
| Moderate and fast, n (%) | SD OCT | 531 (20.1) | 597 (28.3) | 507 (36.7) | 355 (20.8) | 881 (28.9) | 224 (31.0) | 175 (26.5) | 1,635 (26.6) |
| SAP | 82 (3.1) | 284 (13.5) | 193 (14.0) | 41 (2.5) | 180 (5.9) | 129 (17.9) | 209 (31.6) | 559 (9.1) | |
Rates of SD OCT global RNFL thickness change: slow if slower −1.0 μm/year; moderate, if between −1.0 and −2.0 μm/year; fast, if faster than −2.0 μm/year.
Rates of SAP MD change: slow if slower than −0.5 dB/year; moderate if between −0.5 and −1.0 dB/year; fast if faster than −1.0 dB /year.
GS = glaucoma suspect; MD = mean deviation; POAG = primary open-angle glaucoma; SAP = Standard Automated Perimetry; SD OCT = Spectral-Domain Optical Coherence Tomography; RNFL = retinal nerve fiber layer.