Table 5.
Characteristics of 6 scenarios presented in Tier 3
| Scenario no | Characteristicsa | Qualitative risk |
|---|---|---|
| No ILD | ||
| 1 |
49yrs Ankylosing spondylitis Abatacept |
Very low |
| 2 |
70yrs Rheumatoid arthritis Methotrexate |
Medium |
| With ILD | ||
| 3 |
Scenario 1 AND Indeterminate fibrosis < 20% volume on CT FVC > 60% TLCO > 80% |
Low |
| 4 |
Scenario 2 AND UIP > 40% volume on CT FVC < 60% TLCO < 30% |
High |
| With ILD and serial data | ||
| 5 |
Scenario 3 AND No/Minimal progression on CT < 5% decline FVC < 10% decline TLCO |
Low |
| 6 |
Scenario 4 AND Moderate progression on CT > 5% decline FVC > 10% decline TLCO |
High |
aThe full scenariosare described in the supplementary material