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. 2005 Jun;25(3-4):767–776. doi: 10.1007/s10571-005-3974-6

Long-Lasting Enhancement of Corticostriatal Transmission by Taurine: Role of Dopamine and Acetylcholine

A N Chepkova 1,2, O A Sergeeva 1, H L Haas 1,3,✉
PMCID: PMC11529550  PMID: 16075390

Abstract

1. Taurine applied to mouse brain slices evokes a long-lasting enhancement (LLE) of corticostriatal synaptic transmission, LLETAU.

2. The occurrence of LLETAU was significantly decreased in the presence of the specific antagonists at either D1 (SCH23390) or D2 (raclopride) dopamine (DA) receptors.

3. LLETAU was prevented by scopolamine, a muscarinic antagonist, and significantly suppressed by the nicotinic antagonist mecamylamine.

4. Thus, dopaminergic and cholinergic mechanisms, in concert with the taurine transporter and glycine receptors, contribute critically to the induction of corticostriatal LLETAU.

Key Words: plasticity, striatum, dopamine, acetylcholine

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