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. 2024 Nov 1;10(44):eado6765. doi: 10.1126/sciadv.ado6765

Fig. 1. PSIP1 is lower expressed in defined T-ALL molecular subgroups and frequently deleted in patients with T-ALL.

Fig. 1.

(A) Graph showing PSIP1 mRNA expression in thymus and T-ALL molecular subgroups after integration of RNA-seq data from 264 patients with T-ALL (22) and primary human thymus samples (24 samples derived from three independent donors) (23). Patients with chromosomal aberration targeting the PSIP1 locus are indicated as orange triangles, and one patient with an additional frame shift mutation (Y18fs) is indicated as a blue square (Kruskal-Wallis test with Dunn’s multiple comparisons test). (B) PSIP1-deleted/mutated T-ALL cases (PSIP1 mut) have lower expression levels of PSIP1 compared to cases with WT PSIP1 alleles (PSIP1 WT) (Mann-Whitney test) (23). *P < 0.05, **P < 0.01, and ****P < 0.0001.