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. 2024 Nov 1;10(44):eadp3481. doi: 10.1126/sciadv.adp3481

Fig. 3. The increase in mtDNA levels does not influence the immune cell populations in the lung and cytokine levels in plasma.

Fig. 3.

(A to L) Relative quantification of immune cells populations analyzed in lungs from control, Kras, TfamO/E, and Kras; TfamO/E mice. (A) Total immune cells (CD45+). (B and C) Dendritic cells type 1 and 2 (cDC1 and cDC2). (D and E) Alveolar and interstitial macrophages. (F) Neutrophils. (G) Eosinophils. (H) B cells. (I) Natural killer (NK) cells. (J and K) CD8+ and CD4+ cells. (L) T regulatory cells (Tregs). **P = 0.005. (M and N) Scatter plots of the levels of selected cytokines and chemokines: interferon-γ (IFN-γ) and growth-regulated alpha protein (CXCL1). *P = 0.0388, **P = 0.0017. (O) Relative transcript levels measured in lung homogenates from Kras and Kras; TfamO/E mice showing the expression levels of IFN-related genes relative to controls (dotted line); n ≥ 4. Scatter plots show individual data points and the mean values ± SD. One-way ANOVA was used for the statistical analysis.