Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
| Cybrid | ETC complex | NT change (AA change) | Oxidative activity | Origin of mtDNA |
|---|---|---|---|---|
| WT | – | – | Full activity | Verified healthy donor |
| ATP6 | V | m.8993 T>G (L156R) | Partial | mtDNA disease maternally inherited Leigh syndrome and neuropathy ataxia and retinitis pigmentosa |
| ND1 | I | m.3460G>A (A52T) | Partial | mtDNA disease Leber hereditary optic neuropathy |
| CO1 | IV | m.6692del (truncation) | Absent | Melanoma patient–derived xenograft |
