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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: Nat Chem Biol. 2024 Apr 24;20(11):1493–1504. doi: 10.1038/s41589-024-01599-0

Extended Data Fig. 4 ∣. MTBH1-2 destabilizes microtubules.

Extended Data Fig. 4 ∣

a–d. Representative cryo-EM images from one of two independent experiments showing microtubules alone or in the presence of excess MTBH1-2. MTBH1-2 at 5 μM with 1 μM GMPCPP-stabilized microtubules polymerized from porcine brain tubulin (a), 1 μM GMPCPP-stabilized microtubules polymerized from unmodified human tubulin affinity purified from tSA201 cells52 (b), 1 μM taxol-stabilized microtubules polymerized from porcine brain tubulin (c) and taxol-stabilized microtubules polymerized from unmodified human tubulin (d). Scale bar, 30 nm.