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. 2013 Dec 16;2013(12):CD008059. doi: 10.1002/14651858.CD008059.pub3

Sires.

Trial name or title NCT01605110
 Effects of Hyperbaric Oxygen Therapy on Surgical Wound Healing (BLEPH)
Methods Randomized controlled trial
Participants Inclusion Criteria: Patients that are able to undergo surgery at the Allure Clinic are capable of undergoing exposure to HBOT, as the contraindications of HBOT are similar to eyelid surgery, with few exceptions.
Exclusion Criteria: Active smokers and those who have quit smoking in the last 12 months, those with known lung disease, seizure disorder, congestive heart failure, known active cancer, previous treatment with specific chemotherapy agents (Doxorubicin, Bleomycin, Disulfiram, Cis‐platinum, Mafenide acetate), those who cannot undergo pressurization/ depressurization because of eustachian‐tube dysfunction and confinement anxiety.
Interventions Intervention: Hyperbaric oxygen therapy: two HBOT treatments (one before and one after surgery) with patients who have undergone upper eyelid surgery. Patients that volunteer to participate in this study will be exposed to two treatments of 100% oxygen at 2.0 atmospheres absolute (ATA)
Comparison: air (sham) 1.2 ATA inside mono‐place chambers for 90 minutes.
Outcomes Reduction of ecchymosis grade (Time Frame: 21 days) clinical signs, reduction of edema (Time Frame: 21 days)
Starting date August 2011 ‐ Anticipated end date: November 2013
Contact information Bryan Sires, MD, FACS (no email address given), Allure Laser Center & Medispa
Notes Location: Washington, USA
Source of funding: Restorix Research Institute, LLLP