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. 2024 Oct 22;9(20):e178645. doi: 10.1172/jci.insight.178645

Figure 2. Stratification of mitochondrial disease patients is revealed by proteomics data.

Figure 2

Stratification of mitochondrial disease patients in proteomics data. PCA of (A) total cell proteomes from the entire patient cohort; (B) mitochondrial proteomes from the entire patient cohort; (C) total cell proteomes from the patient cohort acquired in the first batch; (D) mitochondrial proteomes from the patient cohort acquired in the first batch. Cases with VUS genes are labeled with their respective patient case number (further described in Supplemental Data File 1). VUS cases (genes) include P07 (HTRA2), P18 (POLRMT), P19 (QRSL1), P41 (MRPS23), P48 and P49 (COX20).