Figure 11.

Methamphetamine (meth) causes alkalization of phagosomes in primary macrophages. The pH of phagosomes of primary macrophages that contain Histoplasma capsulatum yeast labeled with pH-sensitive and pH-insensitive probes was measured using a spectrofluorometer after treatment with phosphate-buffered saline (control [ctrl]), meth (10, 25, or 50 μmol/L), or chloroquine (clq) (20 μmol/L). Bars represent the means of 4 measurements, and error bars denote standard deviations. P values were calculated by analysis of variance and adjusted by use of the Bonferroni correction. *P < .001.