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. 2024 Nov 1;7:1424. doi: 10.1038/s42003-024-07062-z

Fig. 8. Nephrocytes exhibit age-dependent changes in transcriptomic and proteomic signatures.

Fig. 8

A Principal component analysis of transcriptome profile alterations among 1-week- (1w), 3-week- (3w) and 5-week- (5w) old PNCs. Circles were added manually. B Heatmap of RNAseq replicates (minimum fold change 1.5, FDR p value cutoff 0.05) from 1-week-old PNCs (red bar), 3-week-old PNCs (light green bar) and 5-week-old PNCs (dark green bar). C KEGG pathways enriched in 3-week-old PNCs, relative to 1-week-old PNCs (transcriptome-based). D KEGG pathways (transcriptome-based) reduced in 3-week-old PNCs, relative to 1-week-old PNCs. E Biological processes increased in 5-week-old PNCs, relative to 1-week-old PNCs (transcriptome-based). F Biological processes reduced in 5-week-old PNCs, relative to 1-week-old PNCs (transcriptome-based). G Heatmap of proteome replicates isolated from 1-week-old PNCs (red bar), 3-week-old PNCs (light green bar) and 5-week-old PNCs (dark green bar). H KEGG pathways enriched in 3-week-old PNCs, relative to 1-week-old PNCs (proteome-based). I KEGG pathways reduced in 5-week-old PNCs, relative to 1-week-old PNCs (proteome-based).