Table 4.
Threshold effect analysis for association between AST/ALT ratio and 28-day all-cause mortality after ICU admission in different models.
| Models | AST/ALT per-unit increase | AST/ALT per-SD increase | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Model I | ||||
| One line effect | 1.18 (1.04, 1.34) | 0.0091 | 1.15 (1.03, 1.27) | 0.0091 |
| Model II | ||||
| Turning point(K) | 2.08 | 0.82 | ||
| AST/ALT < K | 1.47 (1.13, 1.91) | 0.0036 | 1.38 (1.11, 1.71) | 0.0036 |
| AST/ALT > K | 0.98 (0.77, 1.25) | 0.8847 | 0.99 (0.81, 1.20) | 0.8859 |
| P value for LRT test* | 0.025 | 0.025 | ||
Data were presented as HR (95% CI) P value. Model I: linear anaysis. Model II: non-linear analysis. Adjusted for gender, age, ethnicity, BMI, sepsis, COPD, AMI, cardiac arrhythmias, respiratory rate, heart rate, MAP, GCS score, Acute Physiology score III, Apache IV score and WBC.
BMI body mass index, COPD chronic obstructive pulmonary disease, AMI acute myocardial infarction, MAP mean artery pressure, GCS Glasgow Coma Scale, WBC white blood cells. HR hazard ratios, CI confidence interval. LRT logarithm likelihood ratio test.
*P < 0.05 indicates that Model II is significantly different from Model I.