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. 2024 Sep 30;38(6):755–767. doi: 10.1007/s40259-024-00671-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 4 — Primary pharmacodynamic endpoints (engagement set). A Change from baseline in mean (SD) CD19+ cell counts over time for biosimilar natalizumab (biosim-NTZ) versus USA (US)-reference natalizumab (ref-NTZ) and European Union (EU)-ref-NTZ. B Change from baseline in mean (SD) α4-integrin percentage receptor saturation (RS) over time for biosim-NTZ versus US-ref-NTZ and EU-ref-NTZ. IV intravenous, PD pharmacodynamic. Wessels et al. [49]. Reprinted by permission of Informa UK Limited, trading as Taylor & Francis Group, https://www.tandfonline.com