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. 2024 Nov 1;15:610. doi: 10.1007/s12672-024-01459-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 2 — Gene ontology enrichment analysis and the genetic alterations of the CCN family genes. A Volcano plots of the differentially expressed genes in the GSE19826, GSE54129 and GSE79973 databases. B Venn diagram to show the commonly up-regulated genes. C Significantly enriched gene ontology terms of CCN family. D The genetic alteration profiles of the six CCN family genes in STAD from cBioportal. E Genetic alteration frequency of CCN family genes in STAD using cBioPortal. F Relative expression differences of CCN family genes in STAD from HAP database