Table 1.

Subcortical volumes associated with MMSE.

		Estimate	95 % CI	p-value	Adj. R²
Thalamus	Unadj.	−2.43	−3.49 – (−1.36)	<0.001	0.18
	Adj.	−1.41	−2.68 – (−0.14)	0.03	0.25
Cerebellar White Matter	Unadj.	−1.53	−2.66 – (−0.39)	0.009	0.06
	Adj.	−0.24	−1.50 – 1.02	0.70	0.20
Cerebellar Gray Matter	Unadj.	−1.23	−2.40 – (−0.06)	0.04	0.04
	Adj.	−0.09	−1.29 – 1.11	0.88	0.22
Caudate	Unadj.	−1.03	−2.20 – 0.15	0.09	0.02
	Adj.	−1.25	−2.26 – (−0.25)	0.02	0.33
Putamen	Unadj.	−1.96	−3.07 – (−0.86)	<0.001	0.11
	Adj.	−1.93	−2.99 – (−0.86)	<0.001	0.36
Pallidum	Unadj.	−0.91	−2.12 – 0.30	0.14	0.01
	Adj.	−1.08	−2.29 – 0.13	0.08	0.26
Basal Ganglia	Unadj.	−1.85	−3.02 – (−0.67)	0.002	0.10
	Adj.	−2.02	−3.10 – (−0.94)	<0.001	0.36
Cortical Gray Matter	Unadj.	−2.99	−3,98 – (−1.99)	<0.001	0.28
	Adj.	−2.02	−3.35 – (−0.68)	0.003	0.33
Brain Parenchymal Fraction	Unadj.	−3.03	−4.02 – (−2.03	<0.001	0.29
	Adj.	−2.04	−3.31 – (−0.76)	0.002	0.33
Cerebral Microbleeds	Unadj.	1.79	0.67 – 2.91	0.002	0.09
	Adj.	1.03	−0.10 – 2.15	0.07	0.24
Lacunes	Unadj.	1.89	0.77 – 3.00	0.001	0.10
	Adj.	1.17	0.01 – 2.34	0.048	0.25

Note: The table shows the association of volumes with the Mini-Mental State Examination (MMSE) of n = 90 CADASIL patients. The volumes were calculated as percentage of the estimated total intracranial volume per mean volume of both hemispheres. The volumetric variables were standardized and estimates are for each decrement in standard deviation. Volumetric data were missing for cerebellar gray matter (n = 1), caudate (n = 1) and the pallidum (n = 6). Adjustment variables were age, sex, history of stroke, hypertension, diabetes mellitus and the number of cerebral microbleeds and lacunes in the respective subcortical or cortical region.