Table 4.
Subcortical volumes associated with vascular cognitive impairment.
| Odds Ratio | 95 % CI | p-value | ||
|---|---|---|---|---|
| Thalamus | Unadj. | 3.34 | 1.56 – 7.17 | 0.002 |
| Adj. | 3.66 | 1.38 – 9.72 | 0.009 | |
| Cerebellar White Matter | Unadj. | 1.98 | 1.08 – 3.63 | 0.03 |
| Adj. | 1.29 | 0.62 – 2.70 | 0.50 | |
| Cerebellar Gray Matter | Unadj. | 1.99 | 1.09 – 3.65 | 0.03 |
| Adj. | 1.09 | 0.51 – 2.34 | 0.83 | |
| Caudate | Unadj. | 1.40 | 0.80 – 2.47 | 0.24 |
| Adj. | 1.60 | 0.79 – 3.24 | 0.19 | |
| Putamen | Unadj. | 2.01 | 1.06 – 3.82 | 0.03 |
| Adj. | 3.06 | 1.21 – 7.73 | 0.02 | |
| Pallidum | Unadj. | 1.19 | 0.67 – 2.13 | 0.55 |
| Adj. | 1.85 | 0.78 – 4.37 | 0.16 | |
| Basal Ganglia | Unadj. | 1.90 | 0.99 – 3.66 | 0.05 |
| Adj. | 2.55 | 1.09 – 5.96 | 0.03 | |
| Cortical Gray Matter | Unadj. | 3.92 | 1.97 – 7.80 | < 0.001 |
| Adj. | 3.74 | 1.47 – 9.54 | 0.006 | |
| Brain Parenchymal Fraction | Unadj. | 5.05 | 2.19 – 11.65 | < 0.001 |
| Adj. | 4.07 | 1.45 – 11.42 | 0.008 |
Note: The table shows the association of volumes with vascular cognitive impairment defined as Mini-Mental State Examination score of 23 or less (n = 90). The volumes were calculated as percentage of the estimated total intracranial volume per mean volume of both hemispheres. Volumetric data were missing for cerebellar gray matter (n = 1), caudate (n = 1) and the pallidum (n = 6). The volumetric variables were standardized and odds ratio are for each decrement in standard deviation. Adjustment variables were age, sex, history of stroke, hypertension, diabetes mellitus and the number of microbleeds and microbleeds within the specific region.