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. 2024 Nov 2;15:9468. doi: 10.1038/s41467-024-53666-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — a Overview of experimental design. Corpus callosum injection with saline (PBS) and a compound toxic to oligodendrocytes (LPC) used to induce demyelination with n = 3 mice per condition per time point across four time points. b UMAP embeddings of non-neuronal cells from PBS (control) and LPC conditions across all time points colored by annotation of major cell type. ECs highlighted in red. UMAP embeddings of ECs across all time points colored by PBS/LPC sample-level labels (c), and Seurat cluster labels (d). e Relative abundance of case-control cell identities across Seurat clusters. f Violin plots of HiDDEN continuous perturbation scores split over PBS and LPC labels and grouped by time point. g Swarmplot of HiDDEN continuous perturbation scores for the 3dpi cells colored by original PBS/LPC labels (left) and with color indicating the refinement of LPC cells into affected (LPC1) and unaffected (LPC0) (right). Source data of (b, c, d, e, f, g) are provided as a Source Data file.