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. 1986 Jan 15;233(2):617–620. doi: 10.1042/bj2330617

Enzymic imbalance in serine metabolism in rat hepatomas.

K Snell, G Weber
PMCID: PMC1153072  PMID: 3082329

Abstract

The activity of 3-phosphoglycerate dehydrogenase was high in tissues of high cell-renewal capacity, and was increased in neonatal and regenerating liver and, more markedly, in hepatomas. Serine hydroxymethyltransferase activity was present in hepatomas, whereas other enzymes of serine utilization (serine dehydratase and serine aminotransferase) were absent. This enzymic imbalance couples serine biosynthesis preferentially to nucleotide precursor formation in cancer cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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