Skip to main content
PMC home page
Biochemical Journal logoLink to Biochemical Journal
. 1986 Jan 15;233(2):617–620. doi: 10.1042/bj2330617

Enzymic imbalance in serine metabolism in rat hepatomas.

K Snell, G Weber
PMCID: PMC1153072  PMID: 3082329

Abstract

The activity of 3-phosphoglycerate dehydrogenase was high in tissues of high cell-renewal capacity, and was increased in neonatal and regenerating liver and, more markedly, in hepatomas. Serine hydroxymethyltransferase activity was present in hepatomas, whereas other enzymes of serine utilization (serine dehydratase and serine aminotransferase) were absent. This enzymic imbalance couples serine biosynthesis preferentially to nucleotide precursor formation in cancer cells.

Full text

PDF
619

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baló-Banga J. M., Weber G. Increased 5-phospho-alpha-D-ribose-1-diphosphate synthetase (ribosephosphate pyrophosphokinase, EC 2.7.6.1) activity in rat hepatomas. Cancer Res. 1984 Nov;44(11):5004–5009. [PubMed] [Google Scholar]
  2. Bridgers W. F. The biosynthesis of serine in mouse brain extracts. J Biol Chem. 1965 Dec;240(12):4591–4597. [PubMed] [Google Scholar]
  3. Davis J. L., Fallon H. J., Morris H. P. Two enzymes of serine metabolism in rat liver and hepatomas. Cancer Res. 1970 Dec;30(12):2917–2920. [PubMed] [Google Scholar]
  4. Eichler H. G., Hubbard R., Snell K. The role of serine hydroxymethyltransferase in cell proliferation: DNA synthesis from serine following mitogenic stimulation of lymphocytes. Biosci Rep. 1981 Feb;1(2):101–106. doi: 10.1007/BF01117006. [DOI] [PubMed] [Google Scholar]
  5. Hayashi S., Tanaka T., Naito J., Suda M. Dietary and hormonal regulation of serine synthesis in the rat. J Biochem. 1975 Jan 1;77(1?):207–219. [PubMed] [Google Scholar]
  6. Knox W. E., Herzfeld A., Hudson J. Phosphoserine phosphatase distribution in normal and neoplastic rat tissues. Arch Biochem Biophys. 1969 Jul;132(2):397–403. doi: 10.1016/0003-9861(69)90381-6. [DOI] [PubMed] [Google Scholar]
  7. PIZER L. I. ENZYMOLOGY AND REGULATION OF SERINE BIOSYNTHESIS IN CULTURED HUMAN CELLS. J Biol Chem. 1964 Dec;239:4219–4226. [PubMed] [Google Scholar]
  8. Snell K. Enzymes of serine metabolism in normal, developing and neoplastic rat tissues. Adv Enzyme Regul. 1984;22:325–400. doi: 10.1016/0065-2571(84)90021-9. [DOI] [PubMed] [Google Scholar]
  9. Snell K. Liver enzymes of serine metabolism during neonatal development of the rat. Biochem J. 1980 Aug 15;190(2):451–455. doi: 10.1042/bj1900451. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Walsh D. A., Sallach H. J. Purification and properties of chicken liver D-3-phosphoglycerate dehydrogenase. Biochemistry. 1965 Jun;4(6):1076–1085. doi: 10.1021/bi00882a015. [DOI] [PubMed] [Google Scholar]
  11. Weber G. Biochemical strategy of cancer cells and the design of chemotherapy: G. H. A. Clowes Memorial Lecture. Cancer Res. 1983 Aug;43(8):3466–3492. [PubMed] [Google Scholar]
  12. Weber G., Queener S. F., Ferdinandus J. A. Control of gene expression in carbohydrate, pyrimidine and DNA metabolism. Adv Enzyme Regul. 1970;9:63–95. doi: 10.1016/s0065-2571(71)80038-9. [DOI] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES