Table 1.

A detailed description of RSS and other formulations used in the glioma patients.

Sr. No.	Name of the medicine	Contents	Properties as per Ayurvedic texts	Mode of action in patients	Reported pharmacological Actions
1.	Raupya Suvarna Sutashekhar Rasa	Raupya Bhasma (incinerated silver), Suvarna Bhasma (incinerated gold), Kajjali (black sulphide of mercury), Tamra Bhasma (incinerated copper), Shankha Bhasma (incinerated conch), Processed Tankan (purified borax powder) Herbs-Shunthi root (Zinziber officinale), Marich fruit (Piper nigrum), Pippali fruit (Piper longum), Twak bark (Cinnamomum zeylanicum), Ela pods (Elettaria cardamomum), Tamalpatra leaf (Cinnamomum zeylanicum), Nagkeshar stamens (Me\sua ferrea), Kachora root (Hedychium spicatum), Processed Vatsanabh root (Aconitum ferox), Processed Dhattura seed (Dhatura stramonium), and Bilva Unripe fruit pulp (Aegle marmelos) all in equal proportion triturated with fresh juice of Bhringaraj (Eclipta alba) whole plant.	Raupya-Suvarna Bhasma Best in scraping of unwanted vitiated Dhatu (Paramlekhana), improving strength, stamina, and immunity, cardiotonic, improving intelligence, prolonging young age, Improving metabolic fire. [25, 16/46–51, 15/69–80] Kajjali- Yogavahi (carrier of qualities of other components) [25, 6/112] Shankha bhasma- reduces Hyperacidity, Grahi (absorptive), Vishagna (removes toxins) [25, 12/21] Herbs: Improve metabolic fire, digestion and absorptive, used in Brain related disorders (Shirortinut). [38, 2/63, 3/63, 3/100, 4/241] Visha dravya: Increases blood circulation, worm manifestation	•Reduce pain, nausea, vomiting in patients. •Pacifying action on the nerves. •Improve immunity, digestion and metabolism.	Antitoxin, immunomodulator, nootropic, antirheumatic, antimicrobial, antiviral, and a tonic for the nervous system. [27] Anxiolytic effect [28] Analgesic, anti-inflammatory, anti-anxiety, cognitive, antidepressant, neuroleptic, and antiepileptic effects on the body [26]
2.	Mauktik Kamduddha	Shankha bhasma (Incinerated Conch) Kapardika bhasma, (Incinerated Cowry) Mukta-shukti bhasma (Incinerated Pearl oyster) Pravala bhasma (Incinerated Coral) Suvarnagairik (Purified ochre) Guduchi satva (Starch from Tinospora cordifolia)	Kamduddha rasa is cold in potency (Sheeta veerya), effective on the digestive system, circulation, nervous system, and urinary system, alleviates pitta dosha (Pittashamana), Anti-pyretic (Jwaraghna) Beneficial in Amlapitta, dizziness (Bhrama), and mental disturbance (Unmada), and reduces body heat (Dahashamana), balances acid production in the stomach, reduces inflammation of the organs of the digestive system, and lowers the tendency of bleeding.	•Minimize side effects of chemotherapy and help to reduce toxins accumulated in the body. •Reduce body heat and inflammation of the digestive system. •Improve digestion.	Incinerated minerals containing Calcium carbonate reduce heartburn by significantly improving peristalsis movement and acid clearance [39].
3.	Liv Atharva Liquid	Kumari swaras (Aloe vera), Dhataki (Woodfordia fruticosa) Haridra (Curcuma longa), Pippali (Piper longum), Vidanga (Emblica ribes) Haritaki (Terminalia chebula), Guda (Jaggery) etc.		•Useful in Liver disorders, chemotherapy-induced sluggish liver. •Improves appetite & digestion. •Improves general health & resistance against cold and cough. •Helps to purify blood.	anti-inflammatory, analgesic, antioxidant, hepatoprotective properties [40–42]
4.	Pippalyasava	Pippali (Piper longum), Haridra (Curcuma longa), Draksha (Vitis vinifera), Dhataki (Woodfordia fruticosa), Guda (Jaggery) etc.	Depletion of dhatu (Kshaya), Gulma, ascites (Udara) emaciation (Karshya) Grahani anaemia (Pandu) Haemorrhoids (Arsha)	•Good for digestive system functions hampered due to chemotherapy. •Effective in functioning of liver and spleen. •Effective in treating chronic cough, cold, breathlessness.	anti-inflammatory, analgesic, anti-oxidant, hepatoprotective properties [25]