Figure 2. Effect of a Restrictive Strategy Compared With a Liberal Strategy on 30-Day Outcomes.

Results are presented for the full sample and in each group of anemia acuity. Risk ratio (RR) values greater than 1 favor a liberal strategy. Pulmonary complications were transfusion-related acute lung injury, transfusion-associated circulatory overload, pneumonia, and acute respiratory failure. Models were adjusted for age, sex, smoking status (never, ever, current, or unknown), anemia-related comorbidities (cancer, chronic kidney disease, or diabetes), baseline hemoglobin (grams per deciliter), myocardial infarction (MI) type (type 1, type 2, or other), number of anticoagulants (warfarin, heparin, or other) and antiplatelets (aspirin, P2Y12 inhibitor, or glycoprotein IIb/IIIa inhibitor) and included a random effect for clinical site.