Table 1.

Direct PIM1 substrates in various solid cancers

No	Substrate	Cancer Types	Phosphorylation sites	Protein types	Function	References
1	c-Myc	Breast cancer	S62	Transcription factor	Cell proliferation	[40]
2	H3	Breast cancer	S10	Histone proteins	Stimulates transcription of specific subset of myc dependent genes	[40]
3	Notch1	Breast cancer	S2152	Transmembrane protein	Notch1 nuclear localization, cell migration, Glycolytic switch and CSL-dependent tumor growth	[42]
4	Notch3	Breast cancer	S1673	Transmembrane protein	Nuclear localization and CSL-independent tumor growth	[43]
5	AR	Prostate cancer	S213	Transcription factor	Higher grade tumors, castration-resistant disease, and altered AR transcriptional activity	[44, 45]
6	14–3-3 ζ	Prostate cancer	S64	AR co-activator	Altered AR transcriptional activity	[46]
7	NDRG-1	Prostate cancer	S330	Stress responsive protein	Cell migration and invasion	[47]
8	NFATC1	Prostate cancer	S257 S335	Transcription factor	Increased invasion, migration and angiogenesis	[48]
9	Capza1	Prostate cancer	S106 S126	Capping protein	Increase adhesion and migration	[48]
10	Capzb2	Prostate cancer	S182 S192 S226	Capping protein	Increase adhesion and migration	[48]
11	ABI-2	Prostate cancer	S183	Wave regulatory complex protein	Increase protein stability, WARC formation, enhanced actin dynamics and tumor invasion	[49]
12	AKT	HCC	S473	Kinase	Tumor growth, cell invasion and metastasis	[50]
13	RBMY	HCC	-	RNA binding motif protein	Increased proliferation, invasion and migration	[51]
14	eIF4B	Lung cancer	S406	Eukaryotic translation initiation factor	Activation of c-MET downstream signaling pathway	[52]
15	c-Myc	Ovarian cancer	S62	Transcription factor	Increase cell proliferation and glycolysis	[53]