Fig. 3.

Intensity of the immunostaining for TH measured in a selected area of the SNpc of vehicle-treated control (sham-operated) adult male mice and unilaterally AAV9-SynA53T-injected adult male mice treated with vehicle or VCE-00.2 (20 mg/kg) given orally. Treatments were daily and prolonged for 2 weeks. Data corresponded to 24 h after the last dose and were expressed as means ± SEM of more than 5 animals per group. They were analyzed by one-way ANOVA followed by the Tukey test (***p < 0.005 versus vehicle-treated sham-operated mice; ###p < 0.005 versus vehicle-treated AAV9-SynA53T-injected mice). Representative immunostaining images for each experimental group, with indication of the approximate area quantified, are shown in right panels (scale bar = 200 μm)