Figure 2.

Lung function decline difference in populations selected by combined baseline Fe_NO and eosinophil levels. *Estimated from a mixed-effects model with repeated post-BD FEV₁ as outcome, and treatment, age, sex, height, region (pooled country), baseline eosinophil strata, baseline ICS dose level, time since randomization, and Treatment × Time interaction and baseline post-BD FEV₁ as covariates. Intercept and time since randomization are random effects. BD = bronchodilator; Fe_NO = fractional exhaled nitric oxide; FEV₁ = forced expiratory volume in one second; SE = standard error.