Fig. 1.

Efficient depletion of Trps1 from cementoblasts and cementocytes, as well as osteoblasts and osteocytes of the alveolar bone in Trps1^Col1a1 cKO mice. Trps1 immunostaining images showing localization of the Trps1 protein in tooth root and alveolar bone of mandibular first molars in 4 wk old WT and Trps1^Col1a1 cKO mice. In WT mice, Trps1 is highly expressed in cementoblasts (black arrowheads), cementocytes (black arrows), osteoblasts (blue arrowheads), and osteocytes (blue arrows). Trps1^Col1a1 cKO mice have diminished expression of Trps1 in root and alveolar bone. CC–cellular cementum; D–dentin; AB–alveolar bone