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. 2024 Nov 2;14:26390. doi: 10.1038/s41598-024-77733-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Expression of miRNA references in PDX ALL specimens and ALL cell lines of the identification cohort. The expression of RNU6, RNU1A1, SNORD44, miR-532-5p, miR-103a-3p, and 5sRNA were analyzed in previous-defined PDX ALL samples derived from spleen (n = 22), BM (n = 22), or CNS (n = 12), and in ALL cell lines (n = 9). Kruskal–Wallis test was applied to test whether the median CT values of miRNA references vary amongst the ALL sample groups. PDX: patient-derived xenograft; ALL: acute lymphoblastic leukemia; BM: bone marrow; CNS: central nervous system.