Table 1.
Demographics and Participant Baseline Characteristics in the Study and Fellow Eye
| Demographics and Characteristics | Lower BCVA Subgroup (n = 170) | Higher BCVA Subgroup (n = 31) | All (N = 201) | |||
|---|---|---|---|---|---|---|
| Age (yrs), mean (SD) | 30.3 (11.9) | 27.7 (10.1) | 29.9 (11.7) | |||
| Sex: male, n (%) | 170 (100) | 31 (100) | 201 (100) | |||
| Ethnicity: n (%) | ||||||
| Hispanic or Latino | 19 (11.2) | 0 | 19 (9.5) | |||
| Not Hispanic or Latino | 144 (84.7) | 30 (96.8) | 174 (86.6) | |||
| Not reported | 3 (1.8) | 1 (3.2) | 4 (2.0) | |||
| Unknown | 4 (2.4) | 0 | 4 (2.0) | |||
| Race, n (%)∗ | ||||||
| Asian | 6 (3.5) | 2 (6.5) | 8 (4.0) | |||
| Black or African American | 2 (1.2) | 0 | 2 (1.0) | |||
| Multiracial | 0 | 1 (3.2) | 1 (0.5) | |||
| Native Hawaiian or Pacific Islander | 2 (1.2) | 0 | 2 (1.0) | |||
| White |
160 (94.1) |
28 (90.3) |
188 (93.5) |
|||
| Study eye |
Fellow eye |
Study eye |
Fellow eye |
Study eye |
Fellow eye |
|
| BCVA ETDRS letters, mean (SD) | 59.4 (10.30) | 61.0 (17.14) | 77.3 (3.95) | 79.5 (4.80) | 62.2 (11.58) | 63.9 (17.21) |
| MP | ||||||
| Mean sensitivity in center grid (16 loci) (dB), mean (SD) | 8.0 (6.33) | 8.5 (6.43) | 16.2 (6.32) | 15.9 (5.95) | 9.3 (7.00) | 9.6 (6.91) |
| Mean sensitivity in whole grid (68 loci) (dB), mean (SD) | 4.3 (5.00) | 4.7 (5.21) | 8.4 (5.67) | 8.4 (5.69) | 4.9 (5.31) | 5.3 (5.45) |
| LLVA ETDRS letters, mean (SD) | 35.4 (20.75) | 39.2 (21.04) | 63.9 (7.69) | 66.5 (8.79) | 39.8 (21.88) | 43.4 (22.00) |
| LLD ETDRS letters, mean (SD) | 23.9 (14.85) | 21.9 (14.54) | 13.5 (5.40) | 12.8 (5.65) | 22.3 (14.31) | 20.5 (13.94) |
| Pelli–Robson contrast sensitivity score, mean (SD) | 0.923 (0.3987) | 0.969 (0.4144) | 1.427 (0.2408) | 1.458 (0.2826) | 1.001 (0.4199) | 1.045 (0.4342) |
| IOP, mean (SD), mmHg | 13.9 (2.87) | 13.9 (2.89) | 12.1 (2.14) | 12.1 (2.24) | 13.6 (2.84) | 13.6 (2.87) |
| SD-OCT | ||||||
| Central horizontal EZ width (μm), mean (SD) | 832.1 (1098.7) | 877.8 (1003.2) | 2338.2 (1620.8) | 2236.0 (1591.7) | 1062.9 (1304.5) | 1091.0 (1213.8) |
| Central EZ area (mm2), mean (SD) | 0.960 (1.8113) | 1.251 (2.8654) | 5.041 (6.3537) | 4.972 (6.5390) | 1.601 (3.3225) | 1.845 (3.9095) |
| FAF | ||||||
| n | 1 | 3 | 0 | 0 | 1 | 3 |
| Total area of preserved FAF (mm2), mean (SD) | 12.430 (N/E) | 12.480 (7.9701) | N/A | N/A | 12.430 (N/E) | 12.480 (7.9701) |
Lower BCVA subgroup = 34 to 73 ETDRS letters.
Higher BCVA subgroup = ≥74 ETDRS letters.
BCVA = best-corrected visual acuity; dB = decibels; EZ = ellipsoid zone; FAF = fundus autofluorescence; IOP = intraocular pressure; LLD = low-luminance deficit; LLVA = low luminance visual acuity; MP = microperimetry; N/A = not applicable; N/E = not estimable; SD = standard deviation; SD-OCT = spectral domain OCT.
∗
No participants were reported in the ‘American Indian or Alaska Native,’ ‘Other,’ ‘Not reported,’ or ‘Unknown’ categories.