Figure 2.

Individual pharmacokinetic parameter of darunavir stratified by weight-band groups. The solid horizontal lines indicate the geometric mean for each group. (a) Individual darunavir (DRV) area under the concentration–time curve (AUC_0–24h); the dashed line indicates the AUC_0–24h adult median (69.4 h mg/L).¹⁴ (b) Individual DRV maximum concentrations (C_max); the dashed line indicates the C_max adult mean (5.5 mg/L).¹⁴ (c) Individual DRV trough concentrations (C_trough); the upper dashed line indicates the C_trough adult mean (1.4 mg/L),¹⁴ the middle dotted line shows the concentration at 50% (EC₅₀) for resistant virus inhibition²⁷ and the lowest dotted line the EC₅₀ of wild-type virus (0.055 mg/L).²⁸ DRV, darunavir; WT, wild type.