Figure 4.

Relative importance of imaging markers on the first principal component. (A) Free water (FW)-corrected mean diffusivity (MD-t) values of ventral tegmental area (VTA)-anterior cingulate cortex (ACC) tract showed a high contribution to the first principal component (PC1). (B) FW values of the VTA-ACC tract contributed most to PC1 among all imaging markers. %IncMSE is the percentage increase in mean squared error, it is calculated through a perturbation approach, where the predictors’ values are permuted to assess its impact on model accuracy. CMBs = cerebral microbleeds; dlPFC = dorsolateral prefrontal cortex; mOFC = medial orbitofrontal cortex; NAc = nucleus accumbens; vlPFC = ventral lateral prefrontal cortex; WMH = white matter hyperintensities.