Table 3.

Changes of monocytes/macrophages-related intercellular signaling pathways.

Pathways		Intercellular interaction	Signal strength	Roles in signal networks	Figure
High Outgoing Signaling
	ADGRE5	New: Mono/Mac signaling to NK cells and receiving signals from T cells	Heightened: Outgoing signaling toward B cells; Self-signaling	Intensified: Senders Influencers	Figs. 8–1 A-H
	ICAM	New: Mono/Mac signaling to T cells and receiving signals from B cells	Heightened: Incoming signaling from B cells and T cells	Intensified: Senders Receivers Influencers	Figs. 8–1 I-P
	RESISTIN	New: Mono/Mac signaling to DCs, B cells, T cells and NK cells; Mono/Mac self-signaling Absent: Mono/Mac receiving signals from DCs	Heightened: Outgoing signaling toward DCs, B cells, T cells and NK cells; Self-signaling	Intensified: Senders Receivers Influencers	Figs. 8–2 A-H
	BAFF	/	Heightened: Outgoing signaling toward B cells	Intensified: Senders	Figs. 8–2 I-P
High Incoming Signaling
	GALECTIN	/	Heightened: Outgoing signaling toward DCs, B cells, T cells, NK cells and NKT cells; Self-signaling	Intensified: Senders Receivers	Fig. 9A–H
	SEMA4	Absent: Mono/Mac receiving signals from T cells, NK cells and NKT cells	Attenuated: Incoming signaling from T cells, NK cells and NKT cells	Weakened: Senders	Fig. 9I–P
High incoming and outgoing signals
	ANNEXIN	/	Heightened: Incoming signaling from DCs, T cells and NK cells; Self-signaling	Intensified: Senders Receivers Mediators Influencers	Fig. 10A–H
	PECAM1	/	Heightened: Self-signaling	Weakened: Mediators	Fig. 10I–P