Interstitial tissue inflammation (a), Lymphoid accumulation (b), fibrosis (c), emphysema (d), granuloma formation (e) and tissue necrosis (f) score in the lung tissue in control, COPD, COPD groups-treated with 4 and 8 ml/kg CM and dexamethasone (n = 7). Data are presented as mean ± SEM. ∗P < 0.05, ∗∗P < 0.01 and ∗∗∗P < 0.001; compared to the control group. +P < 0.05, +++P < 0.001; compared to COPD. £P < 0.05; compared to COPD group-treated with 4 ml/kg CM group. #P < 0.05; compared to Dexamethasone. Statistical analyses were performed using one-way analysis of variance (ANOVA) with Tukey-Kramer's post-test.