Table 3.
Disease activity markers and flow cytometry results in JDM children with low and normal HDL.
| Low HDL median (IQR) | Normal HDL median (IQR) | p value | |
|---|---|---|---|
| Sample size | 35 | 78 | |
| Clinical disease activity indicators | |||
| DAS total | 8.2 (5.9–13.4) | 1.8 (0–5) | 0.0001 |
| DAS skin | 5 (0-6.5) | 1 (0–4) | 0.01 |
| DAS muscle weakness | 4 (0.5–7.25) | 0 (0–1) | < 0.0001 |
| CMAS | 43 (26–48) | 51 (46–52) | < 0.0001 |
| ERL (#/mm) | 5.1 (3.3–5.8) | 5.5 (4.5–6.3) | 0.03 |
| Laboratory disease activity indicators | |||
| Neopterin (nmol/L) | 11.9 (6.1–21) | 6 (5.2–6.6) | < 0.0001 |
| ESR (mm/h) | 9.5 (6–23) | 7 (4–12) | 0.01 |
| vWF Ag (%) | 127 (107–189) | 100.5 (77.3-143.3) | 0.008 |
| Muscle enzymes | |||
| CK (IU/L) | 88.5 (67.3-136.8) | 82 (59.5–107) | 0.33 |
| AST (IU/L) | 30 (24.5–47) | 26 (20–32) | 0.005 |
| LDH (IU/L) | 273.5 (224.5-330.3) | 195 (163–239) | < 0.0001 |
| Aldolase (U/L) | 6.2 (5.2–7.9) | 5.5 (4.5–6.6) | 0.03 |
| Flow cytometry (percentage) | |||
| T cells (CD3+) | 67 (62–75) | 75 (70–81) | 0.0004 |
| T helper cells (CD3 + CD4+) | 44 (37–49) | 46 (40.8–52) | 0.077 |
| T cytotoxic cells (CD3 + CD8+) | 23 (18–25) | 24.5 (20.8–30) | 0.058 |
| B cells (CD19+) | 22 (16–29) | 15 (10–20) | 0.0007 |
| NK cells (CD16+/CD56+) | 8 (5–11) | 7 (4–12) | 0.54 |