Fig. 1.

Dose-response associations of Life’s Essential 8 score and incident cardiovascular disease, by Life’s Essential 8 score separately and combined using restricted cubic spline models in the Women’s Health Initiative Objective Physical Activity and Cardiovascular Health Study in 40 United States clinical sites, 2012–2014. Abbreviations: LE8, Life’s Essential 8; LE8_A, Life’s Essential 8 score calculated using accelerometer-measured minutes per week of moderate-to-vigorous physical activity; LE8_AQ, Life’s Essential 8 score calculated using sample-based quantiles accelerometer-measured minutes per week of moderate-to-vigorous physical activity; LE8_CHAMPS, Life’s Essential 8 score calculated using the Community Healthy Activities Model Program for Seniors questionnaire; LE8_STEPS, Life’s Essential 8 score calculated using sample-based quantiles accelerometer-measured average steps per day; LE8_WHI, Life’s Essential 8 score calculated using the Women’s Health Initiative’s physical activity questionnaire. Models adjusted for age, race/ethnicity, education, alcohol use, and multimorbidity. Results were trimmed at the 1st and 99th percentiles. Associations were modeled using restricted cubic splines with knots placed at the 10th, 50th, and 90th percentiles, with the referent value placed at a score of 50. All associations were linear only (all p-non-linear > 0.50).