Table 3.
Associations of Life’s Essential 8 score with incident cardiovascular disease by method of physical activity measurement using multivariable Cox regression models in the Women’s Health Initiative Objective Physical Activity and Cardiovascular Health Study in 40 United States clinical sites, 2012–2014.
|
LE8 Score Quartile |
Continuous LE8 Scorea | ||||
|---|---|---|---|---|---|
| Q1 (Least Healthy) | Q2 | Q3 | Q4 (Healthiest) | ||
| LE8WHI | |||||
| Average MVPA min/week (SD) | 19.9 (62.8) | 57.0 (109.7) | 109.5 (136.5) | 190.6 (171.8) | |
| CVD events [rate]b | 223 [28.6] | 204 [25.8] | 159 [19.4] | 121 [5.1] | – |
| Model 1 HR (95 % CI)c | 1 (REF) | 0.85 (0.70, 1.03) | 0.63 (0.51, 0.77) | 0.49 (0.39, 0.62) | 0.81 (0.77, 0.86) |
| Model 2 HR (95 % CI)c | 1 (REF) | 0.88 (0.73, 1.07) | 0.66 (0.54, 0.81) | 0.53 (0.43, 0.67) | 0.83 (0.79, 0.88) |
| LE8CHAMPS | |||||
| Average MVPA min/week (SD) | 123.8 (279.4) | 262.9 (345.0) | 357.7 (388.8) | 471.8 (446.4) | |
| CVD events [rate]b | 238 [29.9] | 193 [25.1] | 162 [20.2] | 114 [13.8] | – |
| Model 1 HR (95 % CI)c | 1 (REF) | 0.83 (0.68, 1.00) | 0.65 (0.53, 0.80) | 0.44 (0.35, 0.55) | 0.80 (0.76, 0.85) |
| Model 2 HR (95 % CI)c | 1 (REF) | 0.85 (0.70, 1.03) | 0.68 (0.56, 0.84) | 0.47 (0.38, 0.60) | 0.82 (0.77, 0.87) |
| LE8A | |||||
| Average MVPA min/week (SD) | 296.1 (215.9) | 356.9 (223.5) | 391.7 (236.8) | 443.8 (258.8) | |
| CVD events [rate]b | 228 [30.0] | 203 [23.9] | 155 [20.3] | 121 [14.8] | – |
| Model 1 HR (95 % CI)c | 1 (REF) | 0.75 (0.62, 0.91) | 0.61 (0.50, 0.75) | 0.42 (0.33, 0.52) | 0.77 (0.72, 0.82) |
| Model 2 HR (95 % CI)c | 1 (REF) | 0.76 (0.63, 0.92) | 0.64 (0.52, 0.78) | 0.44 (0.36, 0.56) | 0.79 (0.74, 0.84) |
| LE8AQ | |||||
| Average MVPA min/week (SD) | 257.3 (166.0) | 329.9 (221.7) | 392.9 (225.9) | 511.8 (262.6) | |
| CVD events [rate]b | 250 [31.4] | 185 [24.9] | 160 [19.6] | 112 [13.4] | – |
| Model 1 HR (95 % CI)c | 1 (REF) | 0.74 (0.61, 0.89) | 0.58 (0.47, 0.70) | 0.41 (0.33, 0.51) | 0.77 (0.72, 0.82) |
| Model 2 HR (95 % CI)c | 1 (REF) | 0.75 (0.62, 0.91) | 0.60 (0.49, 0.74) | 0.44 (0.35, 0.55) | 0.78 (0.74, 0.83) |
| LE8STEPS | |||||
| Average daily steps (SD) | 2630 (1317) | 3310 (1749) | 4048 (3340) | 5383 (5133) | |
| CVD events [rate]b | 235 [31.1] | 209 [26.8] | 156 [18.2] | 107 [13.4] | – |
| Model 1 HR (95 % CI)c | 1 (REF) | 0.80 (0.66, 0.96) | 0.55 (0.45, 0.67) | 0.42 (0.33, 0.52) | 0.77 (0.72, 0.82) |
| Model 2 HR (95 % CI)c | 1 (REF) | 0.82 (0.68, 0.99) | 0.58 (0.47, 0.71) | 0.45 (0.35, 0.57) | 0.79 (0.74, 0.84) |
Abbreviations: CI, confidence interval; CVD, cardiovascular disease; HR, hazard ratio; LE8, Life’s Essential 8; LE8A, Life’s Essential 8 score calculated using accelerometer-measured minutes per week of moderate-to-vigorous physical activity; LE8AQ, Life’s Essential 8 score calculated using sample-based quantiles accelerometer-measured minutes per week of moderate-to-vigorous physical activity; LE8CHAMPS, Life’s Essential 8 score calculated using the Community Healthy Activities Model Program for Seniors questionnaire; LE8STEPS, Life’s Essential 8 score calculated using sample-based quantiles accelerometer-measured average steps per day; LE8WHI, Life’s Essential 8 score calculated using the Women’s Health Initiative’s physical activity questionnaire; MVPA, moderate-to-vigorous physical activity; SD, standard deviation.
Data are from models including LE8 score in models in continuous form expressed per 10-point increase in LE8 score.
Crude incidence rate per 1000 person-years.
Model 1 adjusted for age and race and ethnicity. Model 2 included Model 1 and education level, alcohol use, and multimorbidity.